Bottom-up synthesis of silica polycaprolactone hybrids for bone regeneration

Synthesis and characterization of polycaprolactone for anterior cruciate ligament regeneration.

Anterior cruciate ligament (ACL) is the most frequently torn ligament in the knee, and complete healing is unlikely due to lack of vascularization. Current approaches for the treatment of ACL injuries include surgical interventions and grafting, however recent reports show that surgeries have 94% recurrency, and that repaired tissues are biomechanically inferior to the native tissue. These nece...

A Bottom-Up Approach for the Synthesis of Highly Ordered Fullerene-Intercalated Graphene Hybrids

*Correspondence: Dimitrios Gournis, Department of Materials Science and Engineering, University of Ioannina, Ioannina 45110, Greece e-mail: [email protected] Much of the research effort on graphene focuses on its use as a building block for the development of new hybrid nanostructures with well-defined dimensions and properties suitable for applications such as gas storage, heterogeneous cataly...

Effect of polycaprolactone scaffold permeability on bone regeneration in vivo.

Successful bone tissue engineering depends on the scaffold's ability to allow nutrient diffusion to and waste removal from the regeneration site, as well as provide an appropriate mechanical environment. Since bone is highly vascularized, scaffolds that provide greater mass transport may support increased bone regeneration. Permeability encompasses the salient features of three-dimensional poro...

Titanium foam-bioactive nanofiber hybrids for bone regeneration.

We have reported previously a method to introduce bioactive nanofiber networks through self-assembly into the pores of titanium alloy foams for bone repair. In this study we evaluate the in vitro colonization by mouse pre-osteoblastic cells of these metal-peptide amphiphile hybrids containing phosphoserine residues and the RGDS epitope. The aim was to determine the effect of varying the RGDS ep...

Graphene synthesis: Nanoribbons from the bottom-up.